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Saskia M Brachmann Selected Research

JDQ443

11/2023CRISPR Screening Identifies Mechanisms of Resistance to KRASG12C and SHP2 Inhibitor Combinations in Non-Small Cell Lung Cancer.
12/2022JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
1/2022Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

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Saskia M Brachmann Research Topics

Disease

13Neoplasms (Cancer)
11/2023 - 12/2005
3Breast Neoplasms (Breast Cancer)
12/2009 - 12/2005
2Pancreatic Neoplasms (Pancreatic Cancer)
01/2019 - 01/2012
2Insulin Resistance
03/2005 - 01/2002
1Lung Neoplasms (Lung Cancer)
12/2023
1Melanoma (Melanoma, Malignant)
01/2016
1Blister (Bulla)
04/2005
1Hemorrhage
04/2005
1Hypersensitivity (Allergy)
03/2005
1Hypoglycemia (Reactive Hypoglycemia)
01/2002

Drug/Important Bio-Agent (IBA)

5Phosphatidylinositols (Phosphatidylinositol)IBA
05/2014 - 01/2002
3JDQ443IBA
11/2023 - 01/2022
2AlpelisibIBA
11/2023 - 05/2014
2Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2019 - 01/2012
2Insulin (Novolin)FDA Link
03/2005 - 01/2002
1Cyclin-Dependent Kinase 4IBA
12/2023
1ribociclibIBA
11/2023
1pyrazoleIBA
12/2022
1SHP099IBA
01/2019
1trametinibIBA
01/2019
1Messenger RNA (mRNA)IBA
07/2017
1Somatomedin Receptors (Somatomedin Receptor)IBA
01/2016
1NVP-BKM120IBA
08/2012
1argyrin BIBA
01/2012
1dactolisibIBA
12/2009
1Trastuzumab (Herceptin)FDA Link
10/2009
1LipidsIBA
10/2009
1PTEN Phosphohydrolase (PTEN Phosphatase)IBA
10/2009
1AgarIBA
12/2005
1Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
12/2005
1Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA
04/2005
1Platelet-Derived Growth Factor alpha ReceptorIBA
04/2005

Therapy/Procedure

6Therapeutics
12/2023 - 01/2012